This opening module welcomes learners into the complex and rapidly evolving world of mRNA vaccine innovation. Guided by your instructor, the session explores malaria as one of humanity’s oldest and deadliest adversaries—shaping patterns of migration, public health systems, global medicine, and modern scientific responses. Learners are introduced to why malaria remains a persistent threat, what makes the parasite so difficult to control, and how mRNA vaccine platforms offer a transformative new frontier. This module sets the foundation for advanced discussions on parasitology, immunology, and molecular vaccine design in the modules that follow.